Gather eclectic recommendations from friends and colleagues. Your assistant might frequent a cool music venue; a single girlfriend might know the sexiest lounges; your gym buddy might point you to a picturesque hiking trail.
The local library probably hosts free readings and other events -- check the newspaper for listings. If you live near a big city, take advantage of bundled activity passes, like a Go Card (gocardusa .com) or CityPass (citypass.com), that'll get you into a variety of museums and other sites for one low price.
Dedicate a night to a country you'd like to visit. Try Argentina: Tango at a dance studio, dine at an Argentinean steakhouse, and end the evening at home, sipping wine from Mendoza.
Head to the highest point in town in time for sunset, and remember your camera. In fact, keep your camera handy throughout the week, as you would on a vacation away from home.
Check into an adorable, affordable B&B
(bedandbreakfast.com) and ditch cooking, dishwashing and bed-making for 24 hours. Ask nicely and the innkeeper might share his recipe for stuffed french toast or cinnamon coffee cake.